(Genes for Good), and correlated their genetic makeup with questionnaire data, mostly in relation to a simple query about the number of times one opens the bowels every day (the "stool frequency," as they called it in the study). They studied 167,875 individuals from population-based cohorts in UK (UK Biobank), the Netherlands (LifeLines-Deep), Belgium (Flemish Gut Flora Project), Sweden (PopCol) and U.S. They may be hidden in our genome, it turns out.Īn international team coordinated by Mauro D'Amato, Ikerbasque Research Professor at CIC bioGUNE in Spain, in a research article published online in the journal Cell Genomics, have demonstrated for the first time that the frequency of defecation is a heritable character in humans, and that specific genetic profiles influence bowel habits as well as predisposition to IBS. The precise mechanisms regulating peristalsis (the action of intestinal muscles pushing food and feces along the GI tract), as well as the reasons why this is often altered in IBS, are unknown. Irregular bowel habits and altered gut motility, including constipation and diarrhea, are often observed in common gastrointestinal conditions like irritable bowel syndrome (IBS), a disorder that affects up to 10% of the population worldwide. How often people move the bowels is important for wellbeing, and reflects correct functioning of the gastrointestinal (GI) tract in digesting and absorbing nutrients, while excreting waste products of digestion and toxic substances.
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